The woeful Red Devils conceded four home first-half goals in the Premier League for the first time having taken a second-minute lead through Bruno Fernandes' penalty.
Tanguy Ndombele levelled before Kane brilliantly set up Son to put Tottenham ahead before the favour was returned shortly after Anthony Martial was sent off, the Frenchman retaliating by striking Erik Lamela in the face after he appeared to be caught by a straw arm himself.
Son had a deserved second prior to the break, before the brilliant Serge Aurier added a fifth and Kane's late penalty meant the scoreline matched United's 6-1 defeat to rivals Manchester City in October 2011 and completed a joy-of-six return for ex-Red Devils boss Jose Mourinho.
Fernandes rolling in the early spot-kick after Davinson Sanchez clumsily chopped down Martial was as good as it got for United.
Harry Maguire and Eric Bailly's woeful defending allowed Ndombele to smash home via a deflection and Son brilliantly dinked over David de Gea after Kane's quick-thinking at a free-kick caught United's defence cold.
Martial's red card for raising a hand to the face of Lamela preceded more abject defending, with Bailly picked off by Kane before the England striker stroked home Son's return pass.
Remarkably it was 4-1 when Son got the run on Bailly to prod in Aurier's low centre before the break.
Aurier then drilled in Spurs' fifth after collecting Pierre-Emile Hojbjerg's exquisite throughball at the end of a fine team move.
Paul Pogba, who failed to track Aurier for the fifth, completed a miserable outing by crudely bringing down Ben Davies, allowing Kane to lash home his second from the spot.
Kane and Son shine for scintillating Spurs
Mourinho's first return to Old Trafford as Spurs boss ended in a 2-1 defeat last December but his superstar forwards meant it was a much happier occasion for the Portuguese this time.
Kane and Son have now combined for 26 Premier League goals, the fifth-most of any duo in the competition's history and the most of any current pairing. At times they were unplayable.
