The Uruguay international scored four and laid on three more in a superb display at Estadio Riazor, setting a La Liga record in the process, with the Catalans in sparkling form.
La Liga
Karim Benzema, Isco, Gareth Bale, James Rodriguez and Gareth Bale all found the net as Los Blancos cruised to victory on Saturday, with the Frenchman in inspired form.
The Portuguese become the first player in history to score 30+ goals in six consecutive Liga seasons as Los Blancos returned to winning ways in style on home soil.
- La Liga
- Hits: 1603
Atletico Madrid 5-1 Real Betis: Griezmann at the double to apply pressure on Barca
Antoine Greizmann netted either side of half-time as Diego Simeone's men ran riot at the Vicente Calderon, downing their Andalusian opponents with a devastating display.
- La Liga
- Hits: 1488
Sevilla 1-2 Athletic Club (agg 3-3, pen 5-4): Holders survive scare to reach semi-finals
Goals from Artiz Aduriz and Raul Garcia secured victory for the visitors on the night, but Benat's penalty miss in the shootout allowed Kevin Gameiro to secure a last-four berth.
The reigning champions will fancy their chances of progressing to the semi-finals after picking up an away win against the Basque side in Thursday's first-leg clash.
The Blancos moved within one point of second-placed Atletico with an accomplished win, despite Cristiano Ronaldo erring from the penalty spot and a ruled out effort.
The Catalans fell to a second successive defeat following their Clasico loss to Real Madrid at the Anoeta Stadium, with Mikel Oyarzabal's headed goal proving decisive.
The visitors came from behind to earn a remarkable victory at Camp Nou, in a result that simultaneously dents the hosts' title hopes and boosts those of Atletico Madrid.
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