Jurgen Klopp's men remain within six points of leaders Chelsea after seeing off the challenge of the Citizens at Anfield, with an early goal making the difference.
Premier League
Jon Walters opened the scoring at Anfield, but Jurgen Klopp's side hit back through Adam Lallana, Roberto Firmino, a Giannelli Imbula own goal and Daniel Sturridge.
The Spain international hit before half time to break the Black Cats' resolve, as Antonio Conte's men kept a firm hold on the Premier League summit.
Antonio Conte's side have gone four points clear at the top of the Premier League after an impressive comeback win at the Etihad Stadium despite their defender's blunder on the ...
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Manchester United 3-1 Sunderland: Mkhitaryan magic seals unhappy Moyes return
The Armenian brought Old Trafford to its feet with a sublime back-heel flick as Jose Mourinho's men eventually overcame stubborn resistance to win comfortably.
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Manchester United 1-0 Tottenham: Mkhitaryan winner earns Red Devils victory
The Armenian struck his second goal in as many games for the Red Devils as Jose Mourinho's men picked up a crucial Premier League victory at Old Trafford on Sunday.
Jurgen Klopp's men ran out deserved winners with a goal in each half and will be favourites to progress to the quarter-finals ahead of the second leg at Old Trafford.
The striker hit home in the 94th minute to break open a game that appeared to be heading towards stalemate, sending the Reds back up to second place behind Chelsea.
The Chile international was the star of the show as the Gunners romped to victory with Mesut Ozil and Alex Oxlade-Chamberlain also on the scoresheet for the visitors.
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