The Bianconeri surrendered a one goal lead to go one behind against the Greek side, but an own goal and a strike from the French midfielder saw them rescue the points.
Diego Simeone's men might have reached the final last season, but they were dealt a rude European awakening as they fell to a surprise defeat at the Karaiskakis Stadium.
The Serie A outfit struggled without their enigmatic striker in their first competitive match under their new coach.
Kostas Mitroglou's cut-back was expertly swept home by the Swiss midfielder to give the Greek champions another shock victory in the group stages.
The England goalkeeper saved two penalties following goals for Stevan Jovetic and Aleksandar Kolarov in normal time, with Dimitris Diomantakos scoring twice.
Diego Simeone's men might have reached the final last season, but they were dealt a rude European awakening as they fell to a surprise defeat at the Karaiskakis Stadium.
The England international produced a neat finish just five minutes in after pouncing on a deflected effort from Daniel Sturridge.
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