The Spain international was returned to the starting XI and opened the scoring, with Gary Cahill's second sending the hosts eight points clear.
Antonio Conte's men did not let the absence of their star striker affect them as they eased to three points at the King Power Stadium on Saturday.
A goal 20 minutes into the encounter was enough to give the home side the advantage in after the first-leg of their EFL Cup semi-final tie.
Two goals from the Croatia international ensured the Nerazzurri carried their good form into 2017, stretching their current streak to four league wins.
The Germany international left it late to secure three points to keep the club's incredible winning Liga run going, after Fabian Orellana had levelled with a stunning shot.
Injuries to Jeremy Mathieu and Andres Iniesta put something of a dampener on the Catalans' victory in Andalucia.
CHICAGO — The Colombian fans were still standing near their seats more than 90 minutes after the Copa America Centenario semifinal between their Cafeteros and Chile was supposed to have ended.
The Argentinian netted a brace and Patrice Evra, Giorgio Chiellini and Leonardo Bonucci scored as Max Allegri's outfit ended another successful season on a high.